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Isoforms of autophagy-related proteins: role in glioma progression and therapy resistance.

Group of Experimental Biotherapy and Diagnostics, Institute for Regenerative Medicine, World-Class Research Center "Digital Biodesign and Personalized Healthcare", Sechenov First Moscow State Medical University, Moscow, Russia, 119991. Endocrine Research Laboratory, Department of Zoology, Kutir Post Graduate College, Chakkey, Jaunpur, UP, India. Group of Experimental Biotherapy and Diagnostics, Institute for Regenerative Medicine, World-Class Research Center "Digital Biodesign and Personalized Healthcare", Sechenov First Moscow State Medical University, Moscow, Russia, 119991. ulasov75@yahoo.com. Institute for Regenerative Medicine, Sechenov First Moscow State Medical University, Moscow, Russian Federation, 119991. Department of Polymers and Composites, N.N.Semenov Institute of Chemical Physics, 4 Kosygin st., Moscow, Russian Federation, 119991. Chemistry Department, Lomonosov Moscow State University, Leninskiye Gory 1-3, Moscow, Russian Federation, 119991. Neuroscience Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran. Tumor Immunology Laboratory, Department of Zoology, Institute of Science, Banaras Hindu University, Varanasi, UP, 221005, India. acharya@bhu.ac.in.

Molecular and cellular biochemistry. 2022;(2):593-604
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Abstract

Autophagy is the process of recycling and utilization of degraded organelles and macromolecules in the cell compartments formed during the fusion of autophagosomes with lysosomes. During autophagy induction the healthy and tumor cells adapt themselves to harsh conditions such as cellular stress or insufficient supply of nutrients in the cell environment to maintain their homeostasis. Autophagy is currently seen as a form of programmed cell death along with apoptosis and necroptosis. In recent years multiple studies have considered the autophagy as a potential mechanism of anticancer therapy in malignant glioma. Although, subsequent steps in autophagy development are known and well-described, on molecular level the mechanism of autophagosome initiation and maturation using autophagy-related proteins is under investigation. This article reviews current state about the mechanism of autophagy, its molecular pathways and the most recent studies on roles of autophagy-related proteins and their isoforms in glioma progression and its treatment.

Methodological quality

Publication Type : Review

Metadata

MeSH terms : Neoplasm Proteins